Population Based Genetic Testing for High-Risk Breast and Ovarian Cancer Predisposition Genes

Grant number: 1126679 | Funding period: 2017 - 2020

Completed

Abstract

Inherited mutations in BRCA1 and BRCA2 confer a very high risk of breast and ovarian cancer. Importantly, once carriers are identified, effective strategies are available that can dramatically reduce the risk of cancer. We will perform genetic testing of a healthy western population to identify breast/ovarian cancer genes before the women develop cancer. Population-based screening could significantly reduce the incidence of these diseases.

Related publications (4)

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Reduced Breast and Ovarian Cancer Through Targeted Genetic Testing: Estimates Using the NEEMO Microsimulation Model

L Petelin, M Cunich, P Procopio, D Schofield, L Devereux, C Nickson, PA James, IG Campbell, AH Trainer

2024-12-01

Background: The effectiveness and cost-effectiveness of genetic testing for hereditary breast and ovarian cancer largely rely on t..

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The Clinical and Psychosocial Outcomes for Women Who Received Unexpected Clinically Actionable Germline Information Identified through Research: An Exploratory Sequential Mixed-Methods Comparative Study

LE Forrest, RF Shepherd, E Tutty, A Pearce, I Campbell, L Devereux, AH Trainer, PA James, MA Young

2022-07-01

Background Research identifying and returning clinically actionable germline variants offer a new avenue of access to genetic info..

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Unselected Women's Experiences of Receiving Genetic Research Results for Hereditary Breast and Ovarian Cancer: A Qualitative Study

R Forbes Shepherd, LE Forrest, E Tutty, A Pearce, L Devereux, PA James, IG Campbell, A Trainer, MA Young

2021-12-01

Background: Although there is growing consensus that clinically actionable genetic research results should be returned to particip..

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Population-based genetic testing of asymptomatic women for breast and ovarian cancer susceptibility

SM Rowley, L Mascarenhas, L Devereux, N Li, KC Amarasinghe, M Zethoven, JEA Lee, A Lewis, JA Morgan, S Limb, MA Young, PA James, AH Trainer, IG Campbell

2019-04-01

Purpose: The identification of carriers of hereditary breast and ovarian cancer (HBOC) gene variants through family cancer history..

University of Melbourne Researchers